Nephroprotective and Anti-Apoptotic Effects of Selenium Nanoparticles in Deltamethrin-Treated Albino Rats

Document Type : Original Article

Authors

1 Research Institute of Medical Entomology, General Organization of Teaching Hospitals and Institutes, Cairo, Egypt

2 National Hepatology and Tropical Medicine Research Institute

3 Research Institute of Medical Entomology, General Organization of Teaching Hospitals

4 Faculty of science - Cairo university

Abstract

Our aim is to evaluate selenium nanoparticles (SeNPs) protective potency towards renal tissues which were exposed to deltamethrin sub lethal dose for one month using corn oil as a solvent. Four groups were assigned (10 rats per group). In the control group rats were fed on corn oil while in the other groups rats were administered SeNPs, deltamethrin and SeNPs along with deltamethrin respectively. Histopathological investigations revealed induced significant renal damage characterized by mononuclear cell infiltration which led to induced marked vacuolar degeneration of epithelial and endothelial lining of renal tubules, glomerular tuft and widening of the Bowman's space in deltamethrin treated rats meanwhile, SeNPs showed protective effect on such tissues. These findings were emphasized by the increased antioxidant activities of superoxide dismutase, catalase and glutathione reductase enzymes among SeNPs treated groups. On the other hand, lipid peroxidase and nitric oxide activities along with urea and creatinine levels showed significant increase in deltamethrin treated groups which was mitigated in SeNPs administered groups. Immuno-histochemical detection of BAX protein (BCL-2- Associated X protein) showed its over expression pattern in deltamethrin group which was also mitigated upon SeNPs treatment. In conclusion, SeNPs exhibit a protective effect against deltamethrin-induced renal damage.

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