Modeling of DNA Radiation damage and Biological Response using Monte Carlo Simulation technique

Salama, Mariam Mohamed; Ali, Mohammed; Khalil, Magdy Mohamed; Moustafa, Mona

doi:10.21608/abas.2024.305610.1047

Modeling of DNA Radiation damage and Biological Response using Monte Carlo Simulation technique

Document Type : Review Article

Authors

¹ physics Department, School of Biotechnology, Badr University.

² Physics Department, Faculty of science, Helwan University.

³ Physics Department, Faculty of Science, Helwan University.

10.21608/abas.2024.305610.1047

Abstract

The simulation of DNA damage and the subsequent biological response using Monte Carlo simulation techniques is a pivotal area of research in radiation biology and biophysics. Monte Carlo simulations offer a powerful tool for understanding the complex interactions between ionizing radiation and biological systems at a microscopic level. This study aims to develop a comprehensive Monte Carlo simulation model to quantitatively assess DNA damage and predict the biological response of cells exposed to various types and doses of radiation.
By modeling the stochastic nature of radiation interactions with biological tissues, we can simulate the generation of primary and secondary ionization events, track the trajectories of ionized particles, and evaluate the resultant DNA damage. The simulation incorporates detailed biological models to account for various types of DNA lesions, including single and double-strand breaks, as well as complex clustered damage sites.
Furthermore, the model extends to simulate the cellular response mechanisms, including DNA repair processes, cell cycle arrest, and apoptosis. By integrating these biological responses into the simulation framework, we can predict the probability and extent of cellular damage and survival, providing insights into dose-response relationships and the efficacy of radioprotective agents.
The results of this simulation study have significant implications for radiotherapy, radiation protection, and our fundamental understanding of radiation-induced carcinogenesis. By providing a detailed mechanistic understanding of DNA damage and repair, the Monte Carlo simulation model serves as a valuable tool for optimizing radiation treatments and developing strategies to mitigate the adverse effects of radiation exposure.
In conclusion, the simulation of DNA damage and biological response using Monte Carlo methods represents a critical advancement in the field of radiation research, offering precise and predictive capabilities that enhance our understanding and management of radiation effects on living organisms.

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